The role of 1,3-dithianes in natural product synthesis
نویسندگان
چکیده
منابع مشابه
Au(PPh3)Cl–AgSbF6-catalyzed rearrangement of propargylic 1,3-dithianes: formation of 8-membered 1,3-bisthio-substituted cyclic allenesw
Au-catalyzed rearrangement of alkynes has attracted considerable attention in recent years. In particular, the Au-catalyzed rearrangement of propargyl acetate generates Au–carbene species through 1,2-acetoxy migration. The Au–carbene species thus generated undergoes a variety of transformations. Moreover, Au-catalyzed rearrangement of propargyl acetate to allene through 1,3-shift of the acetoxy...
متن کاملDirect transformation of 1,3-dihalides into dithianes and dithiepines via a novel one-pot reaction with carbon disulfide and sodium borohydride
[formula: see text] 1,3-Dithianes and -dithiepines are prepared via an experimentally simple and efficient direct transformation of 1,n-alkyl dihalides utilizing carbon disulfide and sodium borohydride.
متن کاملPalladium-catalyzed cross-coupling of 2-aryl-1,3-dithianes.
Palladium-catalyzed cross-coupling of aryl bromides with 2-aryl-1,3-dithianes is described. This methodology takes advantage of the relatively acidic benzylic proton of the dithiane, allowing it to act as a competent, polarity-reversed transmetalation reagent. This unique approach affords the ability to employ an orthogonal deprotection strategy, and practical routes to both diaryl ketones and ...
متن کاملNatural Biopolymers is an Efficient Catalyst for the Synthesis of 1,3,5-Trisubstituted Pyrazoles
Cellulose sulfuric acid is an efficient metal-free catalyst for the synthesis of 1,3,5-trisubstituted pyrazoles via the condensation of 1,3-diketones and hydrazines. The reaction was carried out in Solvent-free condition at room temperature and the products were isolated in good to excellent yields. Mild reaction conditions, as well as ease of operation and workup are some advantages of the pro...
متن کاملWhen ethyl is infinitely different from methyl: double addition of lithiated dithianes to aromatic carboxylates revisited.
Addition of lithiated alkyl dithianes to benzoyl chloride or methyl benzoate does not produce the expected product of double addition, alpha,alpha-bis(alkyldithianyl) benzyl alcohol, for alkyls larger than methyl. Instead, the first step intermediate, i.e. 2-benzoylated dithiane, undergoes an electron-transfer reduction by the second molecule of the dithianyl anion. This reduction is followed b...
متن کامل